The U.S. Agency for International Development (USAID), the Government of Norway, the Bill & Melinda Gates Foundation, Grand Challenges Canada, the U.K.'s Department for International Development (DFID), and the Korea International Cooperation Agency (KOICA) invite global problem solvers to answer their sixth call for groundbreaking prevention and treatment approaches for pregnant women and newborns in poor, hard-to-reach communities around the time of childbirth. Specifically, the challenge seeks to identify and develop transformative approaches that integrate 1) scientific and technological advancements, 2) better service delivery models and, 3) improved "demand side" innovations that empower pregnant women and their families to practice healthy behaviors and be aware of and access health care during pregnancy, childbirth, and the early postnatal period, especially the first two days after birth.